| Date: | 25 April–2 May |
| Edition: | 2nd |
| Surface: | Clay |
| Location: | Tigre, Argentina |
| Champs: |  Camilo Ugo Carabelli |
| Champd: | Guillermo Durán /  Felipe Meligeni Alves |
| Before Year: | 2022 |
| Before Name: | Challenger de Tigre |
| Main Name: | Challenger de Tigre |
| After Name: | Challenger de Tigre |
The 2022 Challenger de Tigre II was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Tigre, Argentina between 25 April and 2 May 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Argentina | Facundo Bagnis | 99 | 1 | |
 Peru | Juan Pablo Varillas | 109 | 2 | |
| Argentina | Camilo Ugo Carabelli | 168 | 3 | |
| Argentina | Renzo Olivo | 169 | 4 | |
| Brazil | Felipe Meligeni Alves | 190 | 5 | |
| Argentina | Nicolás Kicker | 201 | 6 | |
| Argentina | Santiago Rodríguez Taverna | 206 | 7 | |
| Brazil | João Menezes | 251 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Daniel Cukierman
Murkel Dellien Franco Emanuel Egea Santiago de la Fuente Juan Ignacio Galarza Conner Huertas del PinoSee main article: 2022 Challenger de Tigre II – Singles.
Camilo Ugo Carabelli def. Andrea Collarini 7–5, 6–2.See main article: 2022 Challenger de Tigre II – Doubles.
Guillermo Durán / Felipe Meligeni Alves def. 
Luciano Darderi / Juan Bautista Torres 3–6, 6–4, [10–3].