| Date: | 3–9 January |
| Edition: | 1st |
| Surface: | Clay |
| Location: | Tigre, Argentina |
| Champs: |  Santiago Rodríguez Taverna |
| Champd: |  Conner Huertas del Pino / Mats Rosenkranz |
| After Year: | 2022 |
| After Name: | Challenger de Tigre II |
The 2022 Challenger de Tigre was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Tigre, Argentina between 3 and 9 January 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Argentina | Guido Andreozzi | 271 | 1 | |
| Argentina | Santiago Rodríguez Taverna | 302 | 2 | |
| Argentina | Genaro Alberto Olivieri | 313 | 3 | |
| Gonzalo Lama | 322 | 4 | ||
| Argentina | Hernán Casanova | 325 | 5 | |
 Spain | Carlos Gimeno Valero | 329 | 6 | |
| Argentina | Facundo Díaz Acosta | 338 | 7 | |
 Italy | Luciano Darderi | 341 | 8 |
The following players received wildcards into the singles main draw:
Valerio Aboian Juan Manuel La Serna Lautaro MidónThe following player received entry into the singles main draw as an alternate:
Mariano KestelboimThe following players received entry from the qualifying draw:
Leonardo Aboian
Murkel Dellien Federico Agustín Gómez
José PereiraSee main article: 2022 Challenger de Tigre – Singles.
Santiago Rodríguez Taverna def. Facundo Díaz Acosta 6–4, 6–2.See main article: 2022 Challenger de Tigre – Doubles.
Conner Huertas del Pino / Mats Rosenkranz def. Matías Franco Descotte / Facundo Díaz Acosta 5–6 retired.