See main article: 2022 Challenger de Buenos Aires.
Luciano Darderi and Juan Bautista Torres were the defending champions[1] but only Torres chose to defend his title, partnering Thiago Agustín Tirante. Torres lost in the semifinals to Román Andrés Burruchaga and Facundo Díaz Acosta.
Guido Andreozzi and Guillermo Durán won the title after defeating Burruchaga and Díaz Acosta 6–0, 7–5 in the final.