The 2022 Challenger Tenis Club Argentino was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 20 and 26 June 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Juan Pablo Ficovich | 175 | 1 | |
 Brazil | Felipe Meligeni Alves | 214 | 2 | |
| Argentina | Francisco Comesaña | 285 | 3 | |
| Argentina | Gonzalo Villanueva | 294 | 4 | |
 Ecuador | Roberto Quiroz | 308 | 5 | |
 Dominican Republic | Nick Hardt | 314 | 6 | |
 Tunisia | Malek Jaziri | 329 | 7 | |
 Colombia | Nicolás Mejía | 341 | 8 |
The following players received wildcards into the singles main draw:
Valerio Aboian Alex Barrena Juan Bautista OteguiThe following player received entry into the singles main draw as an alternate:
Ignacio MonzónThe following players received entry from the qualifying draw:
Leonardo Aboian Guido Andreozzi Tomás Farjat Juan Ignacio Galarza
Naoki Nakagawa Fermín TentiSee main article: 2022 Challenger Tenis Club Argentino – Singles.
Francisco Comesaña def. Mariano Navone 6–4, 6–0.See main article: 2022 Challenger Tenis Club Argentino – Doubles.
Arklon Huertas del Pino / Conner Huertas del Pino def. Matías Franco Descotte / Alejo Lorenzo Lingua Lavallén 7–5, 4–6, [11–9].