| Date: | 7–13 November 2022 |
| Edition: | 3rd (men) 1st (women) |
| Surface: | Hard / Indoor |
| Location: | Calgary, Canada |
| Category: | ATP Challenger Tour ITF Women's World Tennis Tour |
| Prize Money: | $53,120 (men) $60,000 (women) |
| Champms: | Dominik Koepfer |
| Champmd: |  Maximilian Neuchrist / Michail Pervolarakis |
| Champws: |  Robin Montgomery |
| Champwd: | Catherine Harrison / Sabrina Santamaria |
| Before Year: | 2020 |
| Main Name: | Calgary Challenger |
The 2022 Calgary National Bank Challenger was a professional tennis tournament played on indoor hard courts. It was the third edition of the tournament which was part of the 2022 ATP Challenger Tour and the first edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Calgary, Canada between 7 and 13 November 2022.[1]
See main article: 2022 Calgary National Bank Challenger – Men's singles.
Aleksandar Vukic 6–2, 6–4.See main article: 2022 Calgary National Bank Challenger – Women's singles.
Robin Montgomery def. 
Urszula Radwańska, 7–6(8–6), 7–5See main article: 2022 Calgary National Bank Challenger – Men's doubles.
Maximilian Neuchrist / Michail Pervolarakis def. 
Julian Ocleppo / Kai Wehnelt 6–4, 6–4.See main article: 2022 Calgary National Bank Challenger – Women's doubles.
Catherine Harrison / Sabrina Santamaria def. 
Kayla Cross / Marina Stakusic, 7–6(7–2), 6–4| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Ecuador | Emilio Gómez | 112 | 1 | |
| Canada | Vasek Pospisil | 121 | 2 | |
 Argentina | Juan Pablo Ficovich | 139 | 3 | |
| Australia | Aleksandar Vukic | 145 | 4 | |
| Dominik Koepfer | 181 | 5 | ||
 France | Antoine Escoffier | 215 | 6 | |
| United States | Brandon Holt | 218 | 7 | |
| Canada | Alexis Galarneau | 222 | 8 |
The following players received wildcards into the singles main draw:
Justin Boulais Cleeve Harper Jaden WeekesThe following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Arthur Fery Maks Kaśnikowski Maximilian Neuchrist Alfredo Perez| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United States | Danielle Lao | 217 | 1 | |
 Hong Kong | Eudice Chong | 219 | 2 | |
 India | Karman Thandi | 220 | 3 | |
| United States | Sophie Chang | 233 | 4 | |
| United States | Robin Montgomery | 257 | 5 | |
| United States | Francesca Di Lorenzo | 267 | 6 | |
| United States | Jamie Loeb | 271 | 7 | |
| United States | Catherine Harrison | 282 | 8 |
The following players received wildcards into the singles main draw:
Kayla Cross Alexia Jacobs Mia Kupres Layne SleethThe following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
Elysia Bolton Teah Chavez Carmen Corley Ana Grubor Martyna OstrzygaloThe following player received entry as a lucky loser:
