| Date: | 12–18 September 2022 |
| Edition: | 3rd |
| Surface: | Hard / Outdoor |
| Location: | Caldas da Rainha, Portugal |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000+H |
| Champs: |  Lucrezia Stefanini |
| Champd: |  Adriana Reami / Anna Rogers |
| Before Name: | Portugal Ladies Open |
The 2022 Caldas da Rainha Ladies Open was a professional tennis tournament played on outdoor hard courts. It was the third edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Caldas da Rainha, Portugal between 12 and 18 September 2022.[1]
See main article: 2022 Caldas da Rainha Ladies Open – Singles.
Lucrezia Stefanini def. 
Marina Bassols Ribera, 3–6, 6–1, 7–6(7–3)See main article: 2022 Caldas da Rainha Ladies Open – Doubles.
Adriana Reami / Anna Rogers def. Elysia Bolton / Jamie Loeb, 6–4, 7–5| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Vitalia Diatchenko | 119 | 1 | ||
 Australia | Maddison Inglis | 134 | 2 | |
| Suzan Lamens | 184 | 3 | ||
 Japan | Mai Hontama | 194 | 4 | |
| Lesley Pattinama Kerkhove | 195 | 5 | ||
 United Kingdom | Yuriko Miyazaki | 202 | 6 | |
| Spain | Marina Bassols Ribera | 206 | 7 | |
| Spain | Andrea Lázaro García | 225 | 8 |
The following players received wildcards into the singles main draw:
Georgina García Pérez Hiroko KuwataThe following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
Sakura Hosogi Hina Inoue
Katarina Jokić Taylor Ng
María Portillo Ramírez Adriana Reami Anna RogersThe following player received entry as a lucky loser:
