The 2022 Busan Open was a professional tennis tournament played on hard courts. It was the 19th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Busan, South Korea between 17 and 23 October 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Korea, Republic of | Kwon Soon-woo | 86 | 1 | |
 Moldova, Republic of | Radu Albot | 87 | 2 | |
| Tseng Chun-hsin | 88 | 3 | ||
 Ecuador | ||||
 Australia | Christopher O'Connell | 109 | 5 | |
 Poland | Kamil Majchrzak | 111 | 6 | |
| Australia | James Duckworth | 114 | 7 | |
| Australia | John Millman | 127 | 8 | |
 United States | Christopher Eubanks | 129 | 9 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
See main article: 2022 Busan Open – Singles.
Kamil Majchrzak def. Radu Albot 6–4, 3–6, 6–2.See main article: 2022 Busan Open – Doubles.
Marc Polmans / Max Purcell def. Nam Ji-sung / Song Min-kyu 6–7(5–7), 6–2, [12–10].
