| Date: | 19–25 September 2022 |
| Edition: | 4th |
| Surface: | Hard / Outdoor |
| Location: | Berkeley, California, United States |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Madison Brengle |
| Champd: | Elvina Kalieva / Peyton Stearns |
The 2022 Berkeley Tennis Club Challenge was a professional tennis tournament played on outdoor hard courts. It was the fourth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Berkeley, California, United States between 19 and 25 September 2022.[1]
See main article: 2022 Berkeley Tennis Club Challenge – Singles.
Madison Brengle def. 
Yuan Yue, 6–7(3–7), 6–3, 6–2See main article: 2022 Berkeley Tennis Club Challenge – Doubles.
Elvina Kalieva / Peyton Stearns def. Allura Zamarripa / Maribella Zamarripa, 7–6(7–5), 7–6(7–5)| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United States | Madison Brengle | 62 | 1 | |
| China | Yuan Yue | 107 | 2 | |
| United States | Katie Volynets | 112 | 3 | |
 Belgium | Greet Minnen | 141 | 4 | |
| United States | Robin Anderson | 152 | 5 | |
| United States | Sachia Vickery | 172 | 6 | |
| United States | Katrina Scott | 179 | 7 | |
| United States | Louisa Chirico | 191 | 8 |
The following players received wildcards into the singles main draw:
Jenna DeFalco Rachel Gailis Maegan ManasseThe following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
Jessica Luisa Alsola Kylie Collins Makenna Jones Robin Montgomery Katja Wiersholm
Lisa Zaar Maribella Zamarripa