| Champ: |  Matteo Berrettini |
| Runner: |  Andy Murray |
| Score: | 6–4, 5–7, 6–3 |
| Draw: | 28 (4 / 3) |
| Seeds: | 8 |
| Type: | singles doubles |
| Before Name: | MercedesCup – Singles |
| Main Name: | Stuttgart Open |
See main article: article and 2022 BOSS Open.
Matteo Berrettini defeated Andy Murray in the final, 6–4, 5–7, 6–3 to win the singles tennis title at the 2022 Stuttgart Open.
Marin Čilić was the defending champion,[1] but chose not to participate.
The top four seeds receive a bye into the second round.