See main article: 2022 BNP Paribas Open.
| Champ: |  Taylor Fritz |
| Runner: |  Rafael Nadal |
| Score: | 6–3, 7–6(7–5) |
| Draw: | 96 (12 / 5) |
| Seeds: | 32 |
| Main Name: | Indian Wells Masters |
Taylor Fritz defeated Rafael Nadal in the final, 6–3, 7–6(7–5) to win the men's singles title at the 2022 Indian Wells Masters. It was his first Masters 1000 title and second career title overall. Fritz became the first American to win the title since Andre Agassi in 2001, and ended Nadal's 20-match winning streak, dating back to the 2022 Melbourne Open.
Cameron Norrie was the defending champion,[1] but lost in the quarterfinals to Carlos Alcaraz, who became the youngest Indian Wells semifinalist since Agassi in 1988.[2]
This was the first ATP Tour tournament since the international governing bodies of tennis (WTA, ATP, ITF, Australian Open, French Open, Wimbledon, US Open) allowed players from Russia and Belarus to continue to participate in tennis events on Tour and at the majors, but not under the name or flag of Russia or Belarus until further notice, due to the 2022 Russian invasion of Ukraine.[3]
Daniil Medvedev and Novak Djokovic were in contention for the world No. 1 singles ranking. Despite his withdrawal from the tournament, Djokovic reclaimed the ranking after Medvedev lost to Gaël Monfils in the third round.[4]
With his third-round win, Nadal became the first player to win 400 Masters matches.[5]
All seeds received a bye into the second round.[6] [7] [8]
The following are the seeded players, based on ATP rankings as of March 7, 2022. Rank and points before are as of March 7, 2022.
As a result of pandemic-related adjustments to the ranking system and changes to the ATP Tour calendar in 2021, ranking points after the tournament (as of March 21, 2022) will be calculated as follows:
| Seed | Rank | Player | Points before | Points dropped (or 19th best result)† | Points won | Points after | Status | |
|---|---|---|---|---|---|---|---|---|
| 1 | 1 | Daniil Medvedev | 8,615 | 250 | 45 | 8,410 | Third round lost to  Gaël Monfils [26] | |
 | 8,465 | (0) | 0 | 8,465 | Withdrew due to not meeting vaccination requirements | |||
| 3 | 3 | Alexander Zverev | 7,515 | 500 | 10 | 7,025 | Second round lost to Tommy Paul | |
| 4 | 4 | Rafael Nadal | 6,515 | (0) | 600 | 7,115 | Runner-up, lost to Taylor Fritz [20] | |
| 5 | 5 | Stefanos Tsitsipas | 6,325 | 300 | 45 | 6,070 | Third round lost to Jenson Brooksby | |
| 6 | 6 |  Matteo Berrettini | 4,928 | 63‡ | 90 | 4,955 | Fourth round lost to Miomir Kecmanović | |
| 7 | 7 | Andrey Rublev | 4,590 | 90+180 | 360+45 | 4,725 | Semifinal lost to Taylor Fritz [20] | |
| 8 | 8 |  Casper Ruud | 3,915 | 90 | 45 | 3,870 | Third round lost to  Nick Kyrgios [WC] | |
| 9 | 9 |  Félix Auger-Aliassime | 3,883 | 90 | 10 | 3,803 | Second round lost to Botic van de Zandschulp | |
| 10 | 10 | Jannik Sinner | 3,495 | 45+90 | 90+24 | 3,474 | Fourth round withdrew against Nick Kyrgios [WC] | |
| 11 | 11 |  Hubert Hurkacz | 3,468 | 45 | 90 | 3,513 | Fourth round lost to Andrey Rublev [7] | |
| 12 | 12 |  Cameron Norrie | 3,305 | 90 | 180 | 3,395 | Quarterfinal lost to Carlos Alcaraz [19] | |
| 13 | 13 | Denis Shapovalov | 3,020 | 45+180 | 45+23 | 2,863 | Third round lost to Reilly Opelka [17] | |
| 14 | 14 |  Diego Schwartzman | 2,660 | (45) | 45 | 2,660 | Third round lost to John Isner [23] | |
| 15 | 15 | Roberto Bautista Agut | 2,480 | 45+150 | 45+45 | 2,375 | Third round lost to Carlos Alcaraz [19] | |
| 16 | 16 | Pablo Carreño Busta | 2,220 | (10) | 10 | 2,220 | Second round lost to Jaume Munar [Q] | |
| 17 | 17 | Reilly Opelka | 2,156 | (0) | 90 | 2,246 | Fourth round lost to Rafael Nadal [4] | |
| 18 | 18 |  Nikoloz Basilashvili | 2,121 | 250 | 45 | 1,916 | Third round lost to Cameron Norrie [12] | |
| 19 | 19 | Carlos Alcaraz | 2,056 | (2) | 360 | 2,414 | Semifinal lost to Rafael Nadal [4] | |
| 20 | 20 | Taylor Fritz | 2,010 | 45+90 | 1,000+45 | 2,920 | Champion, defeated Rafael Nadal [4] | |
| 21 | 21 | Lorenzo Sonego | 1,937 | 45 | 10 | 1,902 | Second round lost to Benjamin Bonzi | |
| 22 | 22 | Aslan Karatsev | 1,933 | 15+20+500 | 10+10+10 | 1,428 | Second round lost to Steve Johnson [WC] | |
| 23 | 23 | John Isner | 1,801 | 45 | 90 | 1,846 | Fourth round lost to Grigor Dimitrov [33] | |
| 24 | 24 | Marin Čilić | 1,785 | (10) | 10 | 1,785 | Second round lost to Miomir Kecmanović | |
| 25 | 26 | Karen Khachanov | 1,680 | 45+45 | 10+23 | 1,623 | Second round lost to Jenson Brooksby | |
| 26 | 28 | Gaël Monfils | 1,633 | (0) | 90 | 1,723 | Fourth round lost to Carlos Alcaraz [19] | |
| 27 | 29 | Daniel Evans | 1,542 | (20) | 45 | 1,567 | Third round lost to Rafael Nadal [4] | |
| 28 | 30 | Frances Tiafoe | 1,463 | 20+45 | 45+10 | 1,453 | Third round lost to Andrey Rublev [7] | |
| 29 | 31 | Alex de Minaur | 1,451 | (10) | 90 | 1,531 | Fourth round lost to Taylor Fritz [20] | |
| 30 | 32 | Lloyd Harris | 1,393 | 32+310 | 45+5 | 1,101 | Third round lost to Matteo Berrettini [6] | |
| 31 | 33 |  Alexander Bublik | 1,391 | (20) | 45 | 1,416 | Third round lost to Grigor Dimitrov [33] | |
| 32 | 34 | Federico Delbonis | 1,382 | 90 | 10 | 1,302 | Second round lost to Nick Kyrgios [WC] | |
| 33 | 35 | Grigor Dimitrov | 1,381 | 90 | 180 | 1,471 | Quarterfinal lost to Andrey Rublev [7] |
The following player would have been seeded, but withdrew before the tournament began.
| Rank | Player | Points before | Points dropped | Points after | Withdrawal reason | |
|---|---|---|---|---|---|---|
| 25 | Cristian Garín | 1,716 | 250 | 1,466 | Fatigue | |
| 27 | Roger Federer | 1,665 | 45 | 1,620 | Right knee surgery |
Source:[10]