| Date: | 18–24 April 2022 |
| Edition: | 10th |
| Surface: | Clay / Outdoor |
| Location: | Chiasso, Switzerland |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Lucia Bronzetti |
| Champd: |  Anastasia Dețiuc / Miriam Kolodziejová |
| Main Name: | Chiasso Open |
| Before Year: | 2019 |
The 2022 Axion Open was a professional tennis tournament played on outdoor clay courts. It was the tenth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Chiasso, Switzerland between 18 and 24 April 2022.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Italy | Lucia Bronzetti | 89 | 1 | |
 Romania | Mihaela Buzărnescu | 123 | 2 | |
 Spain | Rebeka Masarova | 132 | 3 | |
| Anna Blinkova | 136 | 4 | ||
| Polona Hercog | 137 | 5 | ||
 Hungary | Réka Luca Jani | 140 | 6 | |
| Ylena In-Albon | 142 | 7 | ||
| Arianne Hartono | 166 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry as special exempts:
The following players received entry from the qualifying draw:
Irene Burillo Escorihuela
Elsa Jacquemot Miriam Kolodziejová Anna SiskováSee main article: 2022 Axion Open – Singles.
Lucia Bronzetti def. Simona Waltert, 2–6, 6–3, 6–3.See main article: 2022 Axion Open – Doubles.
Anastasia Dețiuc / Miriam Kolodziejová def. Aliona Bolsova / Oksana Selekhmeteva, 6–3, 1–6, [10–8]