See main article: 2022 Australian Open.
| Type: | grandslamwc |
| Champ: | Diede de Groot |
| Runner: | Aniek van Koot |
| Score: | 6–1, 6–1 |
| Draw: | 8 |
| Seeds: | 2 |
Defending champion Diede de Groot[1] defeated Aniek van Koot in the final, 6–1, 6–1 to win the women's singles wheelchair tennis title at the 2022 Australian Open. It was the first step in an eventual Grand Slam for de Groot.