The 2022 Astana Open was a professional men's tennis tournament to be held on indoor hard courts. It was the third edition of the Astana Open and part of the ATP Tour 500 Series of the 2022 ATP Tour.
The event was held on a third consecutive year in the alternative sporting calendar, but it was upgraded to the ATP 500 level following the cancellation of tournaments in China in 2022 because of the ongoing COVID-19 pandemic.[1] The tournament took place in Astana, Kazakhstan, from 3–9 October.[2] The women's event was discontinued this year.
See main article: 2022 Astana Open – Singles.
Novak Djokovic def. Stefanos Tsitsipas, 6–3, 6–4See main article: 2022 Astana Open – Doubles.
Adrian Mannarino / Fabrice Martin, 6–4, 6–2| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Carlos Alcaraz | 1 | 1 | |
| Daniil Medvedev | 4 | 2 | ||
| Stefanos Tsitsipas | 6 | 3 | ||
| Serbia | Novak Djokovic | 7 | 4 | |
| Andrey Rublev | 9 | 5 | ||
 Italy | ||||
 Poland | Hubert Hurkacz | 11 | 7 | |
 Canada | Félix Auger-Aliassime | 13 | 8 | |
| Marin Čilić | 16 | 9 |
The following players received wildcards into the singles main draw:
The following player received entry as a special exempt:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Nikoloz Basilashvili → replaced by Albert Ramos Viñolas Adrian Mannarino Gaël Monfils → replaced by Oscar Otte Lorenzo Musetti → replaced by 
Emil Ruusuvuori
David Goffin
Diego Schwartzman → replaced by 
Alexander Bublik Jannik Sinner → replaced by 
Pavel Kotov Lorenzo Sonego → replaced by Tallon Griekspoor| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Tim Pütz |  New Zealand | Michael Venus | 15 | 1 | ||
| Nikola Mektić | Mate Pavić | 19 | 2 | |||
| Spain | Marcel Granollers | Argentina | Horacio Zeballos | 23 | 3 | |
 United Kingdom | Lloyd Glasspool | Finland | Harri Heliövaara | 34 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pair received entry from the qualifying draw:
Francisco Cerúndolo / Andrés Molteni
Juan Sebastian Cabal / Robert Farah → replaced by Adrian Mannarino / Fabrice Martin Neal Skupski → replaced by Andrey Golubev / Aleksandr Nedovyesov
Rajeev Ram / Joe Salisbury → replaced by Kevin Krawietz / Andreas Mies
