| Date: | 7–13 February |
| Edition: | 25th |
| Category: | ATP Tour 250 series |
| Prize Money: | $686,700 |
| Draw: | 28S / 16D |
| Surface: | Clay / outdoor |
| Location: | Buenos Aires, Argentina |
| Venue: | Buenos Aires Lawn Tennis Club |
| Champs: |  Casper Ruud |
| Champd: |  Santiago González /  Andrés Molteni |
| Main Name: | ATP Buenos Aires |
The 2022 Argentina Open was a men's tennis tournament played on outdoor clay courts. It was the 25th edition of the ATP Buenos Aires event, and part of the ATP Tour 250 series of the 2022 ATP Tour. It took place in Buenos Aires, Argentina, from 7 to 13 February 2022.[1]
The tournament marked the return of US Open champion and former world No. 3 Juan Martín del Potro of Argentina from knee injury. He had not played an ATP match since June 2019.[2]
See main article: 2022 Argentina Open – Singles.
Casper Ruud def. Diego Schwartzman, 5–7, 6–2, 6–3See main article: 2022 Argentina Open – Doubles.
Santiago González / Andrés Molteni def. 
Fabio Fognini / Horacio Zeballos, 6–1, 6–1| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q | width=85 | Q2 | width=85 | Q1 |
| Singles | 250 | 150 | 90 | 45 | 20 | 0 | 12 | 6 | 0 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Doubles | 0 |
| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q2 | width=85 | Q1 |
| Singles | $91,600 | $53,435 | $31,410 | $18,205 | $10,570 | $6,460 | $3,230 | $1,760 | ||
| Doubles* | $31,830 | $17,030 | $9,970 | $5,580 | $3,290 |
| width=70 | Country | width=175 | Player | Rank1 | Seed |
|---|---|---|---|---|---|
| Norway | Casper Ruud | 8 | 1 | ||
| Argentina | Diego Schwartzman | 14 | 2 | ||
| Italy | Lorenzo Sonego | 23 | 3 | ||
| Italy | Fabio Fognini | 31 | 4 | ||
 Serbia | Dušan Lajović | 38 | 5 | ||
| Argentina | Federico Delbonis | 41 | 6 | ||
 Spain | Albert Ramos Viñolas | 44 | 7 | ||
| Serbia | Laslo Đere | 49 | 8 |
The following players received wildcards into the singles main draw:
The following players received special exempts into the main draw:
The following players received entry using a protected ranking into the singles main draw:
The following players received entry from the qualifying draw:
Dominic Thiem → replaced by 
Thiago Monteiro| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Italy | Argentina | |||||
| Italy | Fabio Fognini | Argentina | Horacio Zeballos | 77 | 2 | |
| Ariel Behar |  Ecuador | Gonzalo Escobar | 77 | 3 | ||
 Bosnia and Herzegovina | Tomislav Brkić | Serbia | Nikola Ćaćić | 79 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pairs received entry as alternates into the doubles main draw:
Facundo Bagnis / Albert Ramos Viñolas → replaced by Andrea Collarini / Mario Vilella Martínez Simone Bolelli / Máximo González → replaced by Hernán Casanova / 
Sergio Galdós Marcelo Demoliner / Miomir Kecmanović → replaced by Miomir Kecmanović / Fernando Romboli Thiago Agustín Tirante → replaced by Marco Cecchinato / Carlos Taberner