| Date: | 28 March – 3 April |
| Edition: | 5th (men) 1st (women) |
| Category: | ATP Challenger 125 (men) WTA 125 (women) |
| Draw: | 32S / 16D (men) 32S / 8D (women) |
| Prize Money: | €134,920 (men) $115,000 (women) |
| Surface: | Clay |
| Location: | Marbella, Spain |
| Venue: | Club de Tenis Puente Romano |
| Champms: |  Jaume Munar |
| Champws: |  Mayar Sherif |
| Champmd: |  Roman Jebavý /  Philipp Oswald |
| Champwd: |  Irina Bara /  Ekaterine Gorgodze |
The 2022 Andalucía Challenger (branded as the 2022 AnyTech365 Andalucía Open for sponsorship reasons) was a professional clay court tennis tournament that took place from 28 March to 3 April 2022 at the Club de Tenis Puente Romano in Marbella, Spain. It was the fifth edition of the men's event and part of the 2022 ATP Challenger Tour.[1] It was also the first edition of the women's event and a part of the 2022 WTA 125 calendar.[2]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Austria | Dominic Thiem | 50 | 1 | |
 Slovakia | Alex Molčan | 65 | 2 | |
| Spain | Pablo Andújar | 67 | 3 | |
| Czech Republic | Jiří Veselý | 77 | 4 | |
| Spain | Roberto Carballés Baena | 79 | 5 | |
| Spain | Jaume Munar | 89 | 6 | |
 Italy | Marco Cecchinato | 93 | 7 | |
| Spain | Carlos Taberner | 94 | 8 |
The following players received wildcards into the singles main draw:
Carlos Gimeno Valero Dominic ThiemThe following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Javier Barranco Cosano Raúl Brancaccio Carlos Gómez-Herrera Lukáš Klein Pol Martín TiffonThe following player received entry as a lucky loser:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Montenegro | Danka Kovinić | 66 | 1 | |
| Varvara Gracheva | 71 | 2 | ||
| Egypt | Mayar Sherif | 73 | 3 | |
| Arantxa Rus | 75 | 4 | ||
 France | Clara Burel | 82 | 5 | |
 Hungary | Panna Udvardy | 83 | 6 | |
| Italy | Martina Trevisan | 88 | 7 | |
| Slovakia | Anna Karolína Schmiedlová | 92 | 8 |
The following players received wildcards into the singles main draw:
The following players entered the main draw using a protected ranking:
Lucia Bronzetti → replaced by Tamara Korpatsch Dalma Gálfi → replaced by 
Mandy Minella Kristína Kučová → replaced by 
Katarzyna Kawa
Greet Minnen → replaced by Rebeka Masarova
Zhu Lin Diane Parry → replaced by Anna Blinkova
Nadia Podoroska → replaced by Anna-Lena Friedsam Alison Van Uytvanck → replaced by Ekaterine Gorgodze Maryna Zanevska → replaced by 
Lesia Tsurenko Zheng Saisai → replaced by 
Aleksandra Krunić| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Serbia | Aleksandra Krunić | Alexandra Panova | 123 | 1 | ||
| Romania | Irina Bara | Georgia | Ekaterine Gorgodze | 127 | 2 |
The following pairs received wildcards into the doubles main draw:
See main article: 2022 Andalucía Challenger – Men's singles.
Jaume Munar def. Pedro Cachin 6–2, 6–2.See main article: 2022 Andalucía Challenger – Women's singles.
Mayar Sherif def. Tamara Korpatsch 7–6(7–1), 6–4See main article: 2022 Andalucía Challenger – Men's doubles.
Roman Jebavý / Philipp Oswald def. Hugo Nys / Jan Zieliński 7–6(8–6), 3–6, [10–3].See main article: 2022 Andalucía Challenger – Women's doubles.
Irina Bara / Ekaterine Gorgodze def. Vivian Heisen / Katarzyna Kawa 6–4, 3–6, [10–6]