The 2022 AFC Champions League knockout stage was played from 18 August 2022 to 6 May 2023.[1] A total of 16 teams competed in the knockout stage to decide the champions of the 2022 AFC Champions League.[2]
The group winners and three best runners-up in the group stage from each region advanced to the round of 16, with both West Region (Groups A–E) and East Region (Groups F–J) having eight qualified teams.
| width=90 | Region | Group | width=220 | Winners | width=220 | Runners-up (best three from each region) |
|---|---|---|---|---|---|---|
| West Region | A | Al-Hilal | Al-Rayyan | |||
| B | Al Shabab | — | ||||
| C | Foolad | Shabab Al-Ahli | ||||
| D | Al-Duhail | — | ||||
| E | Al-Faisaly | Nasaf Qarshi | ||||
| East Region | F | Daegu FC | Urawa Red Diamonds | |||
| G | BG Pathum United | — | ||||
| H | Yokohama F. Marinos | Jeonbuk Hyundai Motors | ||||
| I | Johor Darul Ta'zim | — | ||||
| J | Vissel Kobe | Kitchee |
In the knockout stage, the 16 teams played a single-elimination tournament, with the teams split into the two regions until the final. All ties were played as a single-leg match (Regulations Article 9.1), except for the final, which was played over two legs. Extra time and penalty shoot-out were used to decide the winners if necessary (Regulations Article 9.3 and 10.1).[2]
The schedule of each round was as follows.[1]
| Round | West Region | East Region | |
|---|---|---|---|
| Round of 16 | 19–20 February 2023 | 18–19 August 2022 | |
| Quarter-finals | 23 February 2023 | 22 August 2022 | |
| Semi-finals | 26 February 2023 | 25 August 2022 | |
| Round | First leg | Second leg | |
| Final | 29 April 2023 | 6 May 2023 |
| Qualified | 1A vs | 1B vs | 1C vs | 1D vs | 1E vs | |
|---|---|---|---|---|---|---|
| 2A/2B/2C | 1B* | 1A | 2A | 2B | 2C | |
| 2A/2B/2D | 1D | 2D | 2A | 1A* | 2B | |
| 2A/2B/2E | 1E | 2E | 2A | 2B | 1A* | |
| 2A/2C/2D | 1C* | 2D | 1A | 2A | 2C | |
| 2A/2C/2E | 2C | 2E | 1E* | 2A | 1C | |
| 2A/2D/2E | 2D | 2E | 2A | 1E* | 1D | |
| 2B/2C/2D | 2D | 1C* | 1B | 2B | 2C | |
| 2B/2C/2E | 2C | 1E | 2E | 2B | 1B* | |
| 2B/2D/2E | 2D | 1D* | 2E | 1B | 2B | |
| 2C/2D/2E | 2D | 2E | 1D* | 1C | 2C |
| Qualified | 1F vs | 1G vs | 1H vs | 1I vs | 1J vs | |
|---|---|---|---|---|---|---|
| 2F/2G/2H | 1G* | 1F | 2F | 2G | 2H | |
| 2F/2G/2I | 1I | 2I | 2F | 1F* | 2G | |
| 2F/2G/2J | 1J | 2J | 2F | 2G | 1F* | |
| 2F/2H/2I | 1H* | 2I | 1F | 2F | 2H | |
| 2F/2H/2J | 2H | 2J | 1J* | 2F | 1H | |
| 2F/2I/2J | 2I | 2J | 2F | 1J* | 1I | |
| 2G/2H/2I | 2I | 1H* | 1G | 2G | 2H | |
| 2G/2H/2J | 2H | 1J | 2J | 2G | 1G* | |
| 2G/2I/2J | 2I | 1I* | 2J | 1G | 2G | |
| 2H/2I/2J | 2I | 2J | 1I* | 1H | 2H |
The round of 16 was played over one leg, with the matchups determined by the combination tables based on which group runners-up qualified.|+West Region|+East Region
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The quarter-finals were played over one leg.|+West Region|+East Region
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The semi-finals were played over one leg.|+West Region|+East Region
See main article: article and 2022 AFC Champions League final.