The 2022–23 Women's EHF Champions League knockout stage began on 18 March with the playoffs and ended on 4 June 2023 with the final at the MVM Dome in Budapest, Hungary, to decide the winners of the 2022–23 Women's EHF Champions League. A total of twelve teams competed in the knockout phase.
In the playoffs, the eight teams ranked 2nd–6th in Groups A and B played against each other in two-legged home-and-away matches. The four winning teams advanced to the quarterfinals, where they were joined by the top-two teams of Groups A and B for another round of two-legged home-and-away matches. The four quarterfinal winners qualified for the final four tournament at the MVM Dome in Budapest, Hungary.[1]
The top six teams from Groups A and B qualified for the knockout stage.
| Group | Qualified for quarterfinals | Qualified for playoffs | |||||
|---|---|---|---|---|---|---|---|
| First place | Second place | Third place | Fourth place | Fifth place | Sixth place | ||
| A |  Vipers Kristiansand |  CSM București | Odense Håndbold |  FTC-Rail Cargo Hungaria | RK Krim Mercator |  Brest Bretagne Handball | |
| B | Metz Handball | Győri Audi ETO KC | Team Esbjerg | CS Rapid București |  WHC Budućnost BEMAX | Storhamar Håndball Elite | |
All times are UTC+2 (matches on 18, 19 and 25 March are UTC+1).
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Odense Håndbold won 60–52 on aggregate.----Team Esbjerg won 55–49 on aggregate.----FTC-Rail Cargo Hungaria won 55–46 on aggregate.----CS Rapid București won 54–53 on aggregate.
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Vipers Kristiansand won 71–56 on aggregate.----FTC-Rail Cargo Hungaria won 59–58 on aggregate.----Team Esbjerg won 65–59 on aggregate.----Győri Audi ETO KC won 66–55 on aggregate.
The final four will be held at the MVM Dome in Budapest, Hungary on 3 and 4 June 2023.[2] The draw took place on 9 May 2023.[3] [4]
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