| Club: | Sassuolo |
| Season: | 2022–23 |
| Owner: | Mapei |
| Chairman: | Carlo Rossi |
| Mgrtitle: | Head coach |
| Manager: | Alessio Dionisi |
| Stadium: | Mapei Stadium – Città del Tricolore |
| League: | Serie A |
| League Result: | 13th |
| Cup1: | Coppa Italia |
| Cup1 Result: | Round of 64 |
| League Topscorer: | Domenico Berardi (12) |
| Season Topscorer: | Domenico Berardi (13) |
| Largest Win: | Sassuolo 5–0 Salernitana |
| Largest Loss: | Napoli 4–0 Sassuolo |
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| Prevseason: | 2021–22 |
| Nextseason: | 2023–24 |
The 2022–23 season was the 103rd season in the history of US Sassuolo Calcio and their tenth consecutive season in the top flight. The club participated in Serie A and the Coppa Italia.
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| Date | Player | Coming From | Fee | Notes | |||
|---|---|---|---|---|---|---|---|
| Agustín Álvarez | Peñarol | ||||||
 Kristian Thorstvedt | Genk |
| Date | Player | Moving to | Fee | Notes | |||
|---|---|---|---|---|---|---|---|
 Vlad Chiricheș | Cremonese | ||||||
 Gianluca Scamacca | West Ham | £30.5M + £5M add-ons | |||||
 Filip Đuričić | Sampdoria |
| Date | Player | Moving to | Fee | Notes | |||
|---|---|---|---|---|---|---|---|
| Luca Moro | Frosinone | ||||||
| Giacomo Raspadori | Napoli | Obligation to buy |
See main article: 2022–23 Serie A.
The league fixtures were announced on 24 June 2022.[2]
See main article: 2022–23 Coppa Italia.