The 2022–23 UEFA Youth League knockout phase began on 7 February 2023 with the play-off round and concluded with the final on 24 April 2023 at Stade de Genève in Geneva, Switzerland, to decide the champions of the 2022–23 UEFA Youth League.[1] The semi-finals and final have been traditionally played at the Colovray Stadium in Nyon since the first edition, but for the 2022–23 edition they were moved to the Stade de Genève due to increased interest in the tournament from the supporters of the participating clubs.[2] All matches are played across 90 minutes and penalty shoot-out if necessary.
Times are CET/CEST, as listed by UEFA (local times, if different, are in parentheses).
| Group | width=210 | Winners (enter round of 16) | width=210 | Runners-up (enter play-offs as away team) |
|---|---|---|---|---|
| A | Liverpool | Ajax | ||
| B | Atlético Madrid | Porto | ||
| C | Barcelona | Inter Milan | ||
| D | Sporting CP | Eintracht Frankfurt | ||
| E | Milan | Red Bull Salzburg | ||
| F | Real Madrid | Shakhtar Donetsk | ||
| G | Manchester City | Borussia Dortmund | ||
| H | Paris Saint-Germain | Juventus |
| width=210 | Second round winners (enter play-offs as home team) |
|---|---|
| AZ | |
| Hibernian | |
| Young Boys | |
| Genk | |
| Panathinaikos | |
| Hajduk Split | |
| Rukh Lviv | |
| MTK Budapest |
| Phase | Round | Draw date | First leg | Second leg |
|---|---|---|---|---|
| Knockout phase | Play-offs | 8 November 2022 | 7–8 February 2023 | |
| Round of 16 | 13 February 2023 | 28 February – 1 March 2023 | ||
| Quarter-finals | 14–15 March 2023 | |||
| Semi-finals | 21 April 2023 at Stade de Genève, Geneva | |||
| Final | 24 April 2023 at Stade de Genève, Geneva | |||
The eight second round winners from the Domestic Champions Path were drawn against the eight group runners-up from the UEFA Champions League Path, with the teams from the Domestic Champions Path hosting the match. Teams from the same association could not be drawn against each other.
The draw was conducted on 8 November 2022 at the UEFA headquarters in Nyon. The play-offs were played over one leg on 7 and 8 February 2023.[3] |}
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The draw was conducted on 13 February 2023 at 13:00 CET in the UEFA headquarters in Nyon.[4] The round of 16 was played over one leg on 28 February and 1 March 2023.[1] |}
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The draw was conducted on 13 February 2023 at 13:00 CET in the UEFA headquarters in Nyon.[4] The quarter-finals were played over one leg on 14 and 15 March 2023.[1] |}
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The draw was conducted on 13 February 2023 at 13:00 CET in the UEFA headquarters in Nyon.[4] The semi-finals were played over one leg on 21 April 2023.[1] All four teams were qualified to the semi-finals for the first time ever, ensuring a fourth different champions in a row.[5] |}
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The final was played on 24 April 2023 at Stade de Genève, Geneva.[1]