| Club: | UC Sampdoria |
| Season: | 2022–23 |
| Chrtitle: | President |
| Chairman: | Marco Lanna |
| Mgrtitle: | Head coach |
| Manager: | Marco Giampaolo (until 2 October) Dejan Stanković (from 6 October) |
| Stadium: | Stadio Luigi Ferraris |
| League: | Serie A |
| League Result: | 20th (relegated) |
| Cup1: | Coppa Italia |
| Cup1 Result: | Round of 16 |
| League Topscorer: | Manolo Gabbiadini (7) |
| Season Topscorer: | Manolo Gabbiadini (7) |
| Pattern La1: | _sampdoria2223h |
| Pattern B1: | _sampdoria2223h |
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| Pattern Sh1: | _sampdoria2223h |
| Pattern So1: | _sampdoria2223h |
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| Pattern B2: | _sampdoria2223a |
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| Prevseason: | 2021–22 |
| Nextseason: | 2023–24 |
The 2022–23 season was the 77th season in the history of UC Sampdoria and their 11th consecutive season in the top flight. The club participated in Serie A and the Coppa Italia.
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See main article: 2022–23 Serie A.
The league fixtures were announced on 24 June 2022.[2]
See main article: 2022–23 Coppa Italia.