| Mode: | Basketball |
| Sex: | none |
| Year: | 2022–23 |
| Prev Year: | 2021–22 |
| Next Year: | 2023–24 |
| Team: | Southern Miss Lady Eagles |
| Conference: | Sun Belt Conference |
| Champion: | Sun Belt co-regular season champions |
| Short Conf: | Sun Belt |
| Record: | 21–10 |
| Conf Record: | 13–5 |
| Head Coach: | Joye Lee-McNelis |
| Hc Year: | 19th |
| Asst Coach1: | Jack Trosper |
| Asst Coach2: | Patosha Jeffery |
| Asst Coach3: | Kaitlynn Pacholke |
The 2022–23 Southern Miss Lady Eagles basketball team represented the University of Southern Mississippi during the 2022–23 NCAA Division I women's basketball season. The team was led by nineteenth-year head coach Joye Lee-McNelis, and played their home games at the Reed Green Coliseum in Hattiesburg, Mississippi as a member of the Sun Belt Conference.
The Lady Eagles finished as co-conference regular season champions with a record of 21–10 overall and 13–5 in conference play.
See main article: 2021–22 Southern Miss Lady Eagles basketball team. The Lady Eagles finished 18–12 and 9–8 in conference-play for the 2021–22 basketball season. They lost in the conference tournament quarterfinal to, 50–70, and were unable to secure a bid into the NCAA tournament.
In March 2022, Southern Miss, as well as C-USA members Old Dominion and Marshall, announced that they would be joining the Sun Belt Conference effective July 1, 2022 to compete as full-time members for the 2022–23 season.[1]
|-!colspan=12 style=|Exhibition|-!colspan=12 style=|Non-conference regular season|-!colspan=12 style=|Sun Belt regular season|-!colspan=12 style=| Sun Belt tournament