| Mode: | Basketball |
| Sex: | none |
| Year: | 2022–23 |
| Prev Year: | 2021–22 |
| Next Year: | 2023–24 |
| Team: | Southern Miss Lady Eagles |
| Conference: | Sun Belt Conference |
| Champion: | Sun Belt co-regular-season champions |
| Short Conf: | Sun Belt |
| Record: | 21–10 |
| Conf Record: | 13–5 |
| Head Coach: | Joye Lee-McNelis |
| Hc Year: | 19th |
| Asst Coach1: | Jack Trosper |
| Asst Coach2: | Patosha Jeffery |
| Asst Coach3: | Kaitlynn Pacholke |
The 2022–23 Southern Miss Lady Eagles basketball team represented the University of Southern Mississippi during the 2022–23 NCAA Division I women's basketball season. The team was led by 19th-year head coach Joye Lee-McNelis, and played their home games at the Reed Green Coliseum in Hattiesburg, Mississippi as a member of the Sun Belt Conference.
The Lady Eagles finished as co-conference regular-season champions with a record of 21–10 overall and 13–5 in conference play.
The Lady Eagles finished 18–12 and 9–8 in conference play for the 2021–22 basketball season. They lost in the conference tournament quarterfinal to, 50–70,[1] and were unable to secure a bid into the NCAA tournament.
In March 2022, Southern Miss, as well as C-USA members Old Dominion and Marshall, announced that they would be joining the Sun Belt Conference effective July 1, 2022 to compete as full-time members for the 2022–23 season.[2]
|-!colspan=12 style=|Exhibition|-!colspan=12 style=|Non-conference regular season|-!colspan=12 style=|Sun Belt regular season|-!colspan=12 style=| Sun Belt tournamentSource:[3]