| Tourney Name: | CAF Champions League knockout stage |
| Year: | 2022–23 |
| Matches: | 14 |
| Goals: | 28 |
| Prevseason: | 2021–22 |
| Nextseason: | 2023–24 |
The 2022–23 CAF Champions League knockout stage started on 21 April with the quarter-finals and ended on 11 June 2023 with the final to decide the champions of the 2022–23 CAF Champions League. A total of eight teams competed in the knockout stage.
Times were local.
The schedule was as follows.
| Round | Draw date | First leg | Second leg |
|---|---|---|---|
| Quarter-finals | 5 April 2023 | 21–22 April 2023 | 28–29 April 2023 |
| Semi-finals | 12–13 May 2023 | 19–20 May 2023 | |
| Final | 4 June 2023 | 11 June 2023 |
Each tie in the knockout phase was played over two legs, with each team playing one leg at home. The team that scored more goals on aggregate over the two legs advanced to the next round. If the aggregate score was level, the away goals rule was applied, i.e. the team that scored more goals away from home over the two legs advanced. If away goals were also equal, then extra time was not played and the winners were decided by a penalty shoot-out (Regulations III. 26 & 27).The mechanism of the draws for each round was as follows:
The knockout stage involved the 8 teams which qualified as winners and runners-up of each of the eight groups in the group stage.
| Group | width=200 | Winners | width=200 | Runners-up |
|---|---|---|---|---|
| A | Wydad AC | JS Kabylie | ||
| B | Mamelodi Sundowns | Al Ahly | ||
| C | Raja CA | Simba | ||
| D | Espérance de Tunis | CR Belouizdad |
The bracket of the knockout stage was determined as follows:
| Round | Matchups | |
|---|---|---|
| Quarter-finals | (Group winners hosted second leg, matchups decided by draw, teams from same group cannot play each other)
| |
| Semi-finals | (Matchups and order of legs decided by draw, between winners QF1, QF2, QF3, QF4)
| |
| Final | Winners SF1 and SF2 faced each other in two legs to decide the champions |
The draw for the quarter-finals was held on 5 April 2023.
The first legs were played on 21 and 22 April, and the second legs were played on 28 and 29 April 2023.|}
1–1 on aggregate. Wydad AC won 4–3 on penalties.----Al Ahly won 2–0 on aggregate.----Mamelodi Sundowns won 6–2 on aggregate.----Espérance de Tunis won 2–1 on aggregate.
The draw for the semi-finals was held on 5 April 2023 (after the quarter-finals draw).
The first legs were played on 12 and 13 May, and the second legs were played on 19 and 20 May 2023.|}
Al Ahly won 4–0 on aggregate.----2–2 on aggregate. Wydad AC won on away goals.
See main article: 2023 CAF Champions League final. The first leg was played on 4 June, and the second leg was played on 11 June 2023.|}
Al Ahly won 3–2 on aggregate.