| Date: | 25 – 31 October |
| Edition: | 5th |
| Surface: | Carpet, Indoor |
| Location: | Ismaning, Germany |
| Champs: | Oscar Otte |
| Champd: | Andre Begemann /  Igor Zelenay |
The 2021 Wolffkran Open was a professional tennis tournament played on carpet courts. It was the fifth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Ismaning, Germany between 25 and 31 October 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Australia | Jordan Thompson | 72 | 1 | |
 Czech Republic | Jiří Veselý | 77 | 2 | |
 Italy | Andreas Seppi | 98 | 3 | |
| Yannick Hanfmann | 127 | 4 | ||
| Oscar Otte | 131 | 5 | ||
| Czech Republic | Tomáš Macháč | 140 | 6 | |
 United States | Maxime Cressy | 143 | 7 | |
 France | Quentin Halys | 150 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 Wolffkran Open – Singles.
Lukáš Lacko 6–4, 6–4.See main article: 2021 Wolffkran Open – Doubles.
Igor Zelenay def. Marek Gengel / Tomáš Macháč 6–2, 6–4.
