| Type: | grandslamwc |
| Score: | 6–2, 6–2 |
| Draw: | 8 |
| Seeds: | 2 |
| Before Year: | 2019 |
| After Name: | Wimbledon Championships – Wheelchair women's singles |
| Before Name: | Wimbledon Championships – Wheelchair women's singles |
See main article: 2021 Wimbledon Championships.
Diede de Groot defeated Kgothatso Montjane in the final, 6–2, 6–2 to win the ladies' singles wheelchair tennis title at the 2021 Wimbledon Championships.[1] It was her third Wimbledon singles title, completed a non-calendar-year Grand Slam, and was the third step in an eventual Super Slam.
Aniek van Koot was the defending champion from when the event was last held in 2019,[2] but was defeated in the quarterfinals by Jordanne Whiley.