| Type: | grandslamwc |
| Score: | 6–2, 6–2 |
| Draw: | 8 |
| Seeds: | 2 |
| Before Year: | 2019 |
| After Name: | Wimbledon Championships – Wheelchair women's singles |
| Before Name: | Wimbledon Championships – Wheelchair women's singles |
See main article: 2021 Wimbledon Championships.
Diede de Groot defeated Kgothatso Montjane in the final, 6–2, 6–2 to win the ladies' singles wheelchair tennis title at the 2021 Wimbledon Championships. It was her third Wimbledon singles title, completed a non-calendar-year Grand Slam, and was the third step in an eventual Super Slam.
Aniek van Koot was the defending champion from when the event was last held in 2019,[1] but was defeated in the quarterfinals by Jordanne Whiley.