| Main Name: | Charleston Open |
| Date: | April 5 – 11 |
| Edition: | 48th |
| Category: | WTA 500 |
| Draw: | 56S / 16D |
| Surface: | Green clay |
| Prize Money: | $565,530 |
| Location: | Charleston, United States |
| Venue: | Family Circle Tennis Center |
| Champs: |  Veronika Kudermetova |
| Champd: |  Nicole Melichar / Demi Schuurs |
| Before Year: | 2020 |
| After Year: | 2021 |
| After Name: | MUSC Health Women's Open |
The 2021 Charleston Open (branded as the 2021 Volvo Car Open for sponsorship reasons) tournament was a women's professional tennis tournament played on outdoor clay courts at the Family Circle Tennis Center on Daniel Island in Charleston, South Carolina. It was the 48th edition of the event on the WTA Tour and was classified as a WTA 500 tournament on the 2021 WTA Tour. It was the first of two Charleston Open tournaments in consecutive weeks at the same facility (the second was the 2021 MUSC Health Women's Open),[1] and were the only events of the annual tour's clay court season to be played on green clay. The first tournament of the 2021 doubleheader was the last to be sponsored by Chinese automaker Geely, the owner of Volvo Cars.
Due to the COVID-19 pandemic and local health guidelines impacting the facility's construction timeline, tournament organizers held the event behind closed doors for the second consecutive year after the preceding year's exhibition tournament was held under similar conditions. The main stadium was demolished in 2020 and tournament organizers had originally planned to host the event for up to 3,000 fans on a smaller temporary stadium on the secondary court, named the Althea Gibson Court.[2] [3]
Veronika Kudermetova won her maiden career WTA title in the singles tournament.[4] Nicole Melichar and Demi Schuurs won their third title as a team in the doubles tournament.[5]
See main article: 2021 Volvo Car Open – Singles.
Veronika Kudermetova def. 
Danka Kovinić, 6–4, 6–2See main article: 2021 Volvo Car Open – Doubles.
Nicole Melichar / Demi Schuurs def. 
Marie Bouzková / Lucie Hradecká, 6–2, 6–4| Event | W | F | SF | QF | Round of 16 | Round of 32 | Round of 64 | width=85 | Q | width=85 | Q2 | width=85 | Q1 |
| Women's singles | 470 | 305 | 185 | 100 | 55 | 30 | 1 | 25 | 13 | 1 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Women's doubles | 1 |
| width=130 bgcolor=dfe2e9 | Event | width=80 bgcolor=lime | W | width=85 bgcolor=thistle | F | width=85 bgcolor=ffff00 | SF | width=85 bgcolor=ffebcd | QF | width=85 bgcolor=afeeee | Round of 16 | width=85 bgcolor=afeeee | Round of 32 | width=85 bgcolor=afeeee | Round of 64 | width=85 | Q2 | width=85 | Q1 |
| style=background:#ededed | Women's singles | $68,570 | $50,130 | $26,745 | $12,670 | $6,480 | $4,100 | $3,330 | $2,000 | $1,020 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| style=background:#ededed | Women's doubles | $25,230 | $17,750 | $10,000 | $5,500 | $3,500 |
The following players received wildcards into the main draw:
The following players received entry using a protected ranking into the main draw:
The following players received entry from the qualifying draw:
Magdalena Fręch Desirae Krawczyk Grace Min Asia Muhammad
Kurumi Nara
Storm Sanders
Gabriela Talabă Natalia VikhlyantsevaThe following players received entry as lucky losers:
Irina-Camelia Begu → replaced by 
Leylah Annie Fernandez
Wang Xinyu Anna Blinkova → replaced by 
Tímea Babos Danielle Collins → replaced by 
Martina Trevisan
Fiona Ferro → replaced by Anastasia Potapova Nao Hibino
Kaia Kanepi → replaced by Caroline Dolehide Anett Kontaveit → replaced by 
Harriet Dart Barbora Krejčíková → replaced by Danka Kovinić Ann Li → replaced by Misaki Doi Christina McHale Anastasia Pavlyuchenkova → replaced by Tsvetana Pironkova Jessica Pegula → replaced by 
Zarina Diyas
Rebecca Peterson → replaced by 
Renata Zarazúa Francesca Di Lorenzo Liudmila Samsonova Kateřina Siniaková → replaced by Lauren Davis Madison Brengle Markéta Vondroušová → replaced by Whitney Osuigwe Heather Watson → replaced by Caty McNally| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| United States | Nicole Melichar | Demi Schuurs | 23 | 1 | ||
| Hungary | Tímea Babos | Russian Federation | Veronika Kudermetova | 30 | 2 | |
| China | Xu Yifan | China | Zhang Shuai | 39 | 3 | |
| Alexa Guarachi | United States | Desirae Krawczyk | 39 | 4 |
The following pair received a wildcard into the doubles main draw:
The following pairs received entry into the doubles main draw using protected rankings:
Oksana Kalashnikova / Alla Kudryavtseva Vania King / Yaroslava Shvedova Ellen Perez / CoCo Vandeweghe Ashleigh Barty / Storm Sanders → replaced by Misaki Doi / Nao Hibino Anna Blinkova / Lucie Hradecká → replaced by Oksana Kalashnikova / Alla Kudryavtseva
Spain
Belgium
Tunisia