| Date: | 8–14 November |
| Edition: | 16th |
| Surface: | Clay |
| Venue: | Carrasco Lawn Tennis Club |
| Location: | Montevideo, Uruguay |
| Category: | ATP Challenger 80 |
| Prize Money: | $52,080 |
| Champs: |  Hugo Dellien |
| Champd: |  Rafael Matos / Felipe Meligeni Alves |
| Before Year: | 2019 |
The 2021 Uruguay Open was a professional tennis tournament played on red clay courts in Montevideo. It was the 16th edition of the tournament for the men which was part of the 2021 ATP Challenger Tour.[1] It took place at the Carrasco Lawn Tennis Club in Montevideo, Uruguay between November 8 and 14, 2021. The 2020 edition could not take place due to the COVID-19 pandemic.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Federico Coria | 72 | 1 | |
 Spain | Jaume Munar | 78 | 2 | |
| Argentina | Facundo Bagnis | 79 | 3 | |
| Brazil | Thiago Monteiro | 94 | 4 | |
| Argentina | Francisco Cerúndolo | 115 | 5 | |
 Peru | Juan Pablo Varillas | 128 | 6 | |
| Bolivia, Plurination;al State of | Hugo Dellien | 129 | 7 | |
| Argentina | Tomás Martín Etcheverry | 131 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Francisco Comesaña
Luciano Darderi Facundo Juárez Gonzalo VillanuevaSee main article: 2021 Uruguay Open – Singles.
Hugo Dellien def. Juan Ignacio Londero 6–0, 6–1.See main article: 2021 Uruguay Open – Doubles.
Rafael Matos / Felipe Meligeni Alves def. Ignacio Carou / Luciano Darderi 6–4, 6–4.