See main article: article and 2021 US Open (tennis).
Rajeev Ram and Joe Salisbury defeated the defending champion Bruno Soares and his partner Jamie Murray in the final, 3–6, 6–2, 6–2 to win the men's doubles tennis title at the 2021 US Open. It was the second major title for Ram and Salisbury as a team, following the 2020 Australian Open.[1] Ram and Salisbury saved four match points en route to the title, in the quarterfinals against Matthew Ebden and Max Purcell.[2]
Soares and Mate Pavić were the defending champions,[3] but did not play together. Pavić partnered Nikola Mektić, but lost in the first round to Nathaniel Lammons and Jackson Withrow.[4]
Salisbury also won the mixed doubles title partnering Desirae Krawczyk, becoming the first man to win both the men's doubles and mixed doubles titles at the US Open in the same year since Bob Bryan in 2010.[5]
Nikoloz Basilashvili / 
Andrei Vasilevski → replaced by 
Kwon Soon-woo / 
Divij Sharan
Laslo Đere → replaced by Laslo Đere / Filip Krajinović
Alexander Bublik / 
David Vega Hernández → replaced by Frederik Nielsen / 
Vasek Pospisil
James Duckworth / 
Yoshihito Nishioka → replaced by James Duckworth / Jordan Thompson
Jürgen Melzer / 
Jo-Wilfried Tsonga → replaced by Jürgen Melzer / Marc Polmans