| Champ: |  Max Westphal  Coleman Wong |
| Runner: |  Viacheslav Bielinskyi Petr Nesterov |
| Score: | 6–3, 5–7, [10–1] |
| Before Year: | 2019 |
See main article: article and 2021 US Open (tennis).
Eliot Spizzirri and Tyler Zink were the defending champions, having won the previous edition in 2019, however both players were no longer eligible to participate in junior events. Spizzirri and Zink received a wildcard in the men's doubles event, where they lost in the first round.
Max Westphal and Coleman Wong won the title, defeating Viacheslav Bielinskyi and Petr Nesterov in the final, 6–3, 5–7, [10–1].
All seeds received a bye into the second round.