| Mode: | baseball |
| Year: | 2021 |
| Team: | UC Irvine Anteaters |
| Conference: | Big West Conference |
| Short Conf: | Big West |
| Coachrank: | 16 |
| Cbrank: | 17 |
| Record: | 40–16 |
| Conf Record: | 32–8 |
| Head Coach: | Ben Orloff |
| Hc Year: | 3rd |
| Asst Coach1: | Daniel Bibona |
| Ac1 Year: | 7th |
| Asst Coach2: | J. T. Bloodworth |
| Ac2 Year: | 3rd |
| Asst Coach3: | Mitch Holland |
| Ac3 Year: | 2nd |
| Stadium: | Cicerone Field |
| Champion: | Big West champion |
| Bowl: | NCAA tournament |
| Bowl Result: | Stanford Regional |
The 2021 UC Irvine Anteaters baseball team represented the University of California, Irvine during the 2021 NCAA Division I baseball season. The Anteaters played their home games at Anteater Ballpark as a member of the Big West Conference. They were led by third-year head coach Ben Orloff.
The 2020 UC Irvine Anteaters baseball team notched a 8–7 (0–0) regular-season record. The season prematurely ended on March 12, 2020, due to concerns over the COVID-19 pandemic.
| Player | Position | Round | Overall | MLB Team |
|---|---|---|---|---|
| Trenton Denholm | RHP | 14 | 426 | Cleveland Indians |
| Peter Van Loon | RHP | 16 | 467 | Baltimore Orioles |
| Dillon Tatum | C | 20 | 609 | Minnesota Twins |