| 2021 Tyrone SFC | |
| County: | Tyrone |
| Province: | Ulster |
| Year: | 2021 |
| Level: | Senior |
| Sponsor: | LCC Group |
| Date: | 3 October - 14 November 2021 |
| Num Teams: | 18 |
| Defending Champions: | Dungannon |
| Winners: | Dromore |
| Ordinal: | 4 |
| Manager: | Colm McCullagh[1] |
| Captain: | Conor O'Hara[2] |
| Qualify For: | 2021 Ulster Club SFC |
| Runnersup: | Coalisland |
| Runnerupmanager: | Brian McGuckin |
| Runnerupcaptain: | Pádraig Hampsey[3] |
| Relegated: | Eglish (15th in SFL) Galbally(16th in SFL) Pomeroy(17th in SFL) Edendork (18th in SFL) |
| Previous: | 2020 |
| Next: | 2022 |
The 2021 Tyrone Senior Football Championship was the 116th edition of Tyrone GAA's premier Gaelic football tournament for senior clubs in County Tyrone, Northern Ireland. The championship consisted of 18 teams and had a straight knock-out format. The winners receive the O'Neill Cup and represent Tyrone in the Ulster Senior Club Football Championship. The draw for the championship was made on 15 July 2021.[4]
Dungannon Thomas Clarkes entered as defending champions,[5] but Dromore St Dympna's ended their title defence in the first round.[6]
Dromore went on to win the championship after disposing of Coalisland Fianna in the final.[7] [8] [9]
The following teams have changed division since the 2020 championship season.
Promoted from 2020 Intermediate Championship
Relegated to 2020 Intermediate Championship No relegation[11]