| Date: | 15–21 November |
| Edition: | 3rd |
| Surface: | Hard (Indoor) |
| Location: | Pau, France |
| Champs: |  Radu Albot |
| Champd: | Romain Arneodo /  Tristan-Samuel Weissborn |
The 2021 Teréga Open Pau–Pyrénées was a professional tennis tournament played on indoor hard courts. It was the third edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Pau, France between 15 and 21 November 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Feliciano López | 103 | 1 | |
| Holger Rune | 109 | 2 | ||
 France | Gilles Simon | 118 | 3 | |
| Austria | Dennis Novak | 119 | 4 | |
 Slovakia | Norbert Gombos | 120 | 5 | |
| Maxime Cressy | 128 | 6 | ||
| Moldova, Republic of | Radu Albot | 134 | 7 | |
 Czech Republic | Zdeněk Kolář | 139 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Michael Geerts Calvin Hemery
Georgii KravchenkoSee main article: 2021 Teréga Open Pau–Pyrénées – Singles.
Radu Albot def. Jiří Lehečka 6–2, 7–6(7–5).See main article: 2021 Teréga Open Pau–Pyrénées – Doubles.
Tristan-Samuel Weissborn def. 
Aisam-ul-Haq Qureshi / David Vega Hernández 6–4, 6–2.
