| Date: | 15–21 November |
| Edition: | 2nd |
| Surface: | Hard (Indoor) |
| Location: | Helsinki, Finland |
| Champs: |  Alex Molčan |
| Champd: |  Alexander Erler / Lucas Miedler |
| Before Year: | 2019 |
| After Name: | HPP Open |
The 2021 Tali Open was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Helsinki, Finland between November 15 and November 21, 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Finland | ||||
| Henri Laaksonen | 99 | 2 | ||
| Slovakia | Alex Molčan | 106 | 3 | |
 Belarus | Egor Gerasimov | 113 | 4 | |
| Oscar Otte | 125 | 5 | ||
 United Kingdom | Liam Broady | 127 | 6 | |
| Slovakia | Jozef Kovalík | 135 | 7 | |
 Serbia | Nikola Milojević | 137 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 Tali Open – Singles.
Alex Molčan def. João Sousa 6–3, 6–2.See main article: 2021 Tali Open – Doubles.
Alexander Erler / Lucas Miedler def. Harri Heliövaara / Jean-Julien Rojer 6–3, 7–6(7–2).
