| Score: | 7–6(7–2), 3–6, [10–5] |
| Type: | singles doubles |
| Edition: | 1st |
| After Name: | San Diego Open – Men's doubles |
See main article: article and 2021 San Diego Open.
This was the first edition of the tournament, which was primarily organized to compensate for the cancellation of Asian tournaments in 2021 due to the COVID-19 pandemic.[1]
Joe Salisbury and Neal Skupski won the title, defeating John Peers and Filip Polášek in the final, 7–6(7–2), 3–6, [10–5].