| Date: | 26 April – 2 May |
| Edition: | 21st |
| Surface: | Hard |
| Location: | Salinas, Ecuador |
| Champs: |  Emilio Gómez |
| Champd: |  Nicolás Barrientos /  Sergio Galdós |
| Before Year: | 2021 |
| Before Name: | Salinas Challenger |
| Main Name: | Salinas Challenger |
| After Name: | Salinas Challenger |
The 2021 Salinas Challenger II was a professional tennis tournament played on green hard courts. It was the 21st edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Salinas, Ecuador between 26 April and 2 May 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Ecuador | Emilio Gómez | 184 | 1 | |
 Brazil | João Menezes | 201 | 2 | |
 Dominican Republic | Roberto Cid Subervi | 230 | 3 | |
 Turkey | Altuğ Çelikbilek | 250 | 4 | |
 Japan | Hiroki Moriya | 265 | 5 | |
| Ecuador | Roberto Quiroz | 274 | 6 | |
 Spain | Adrián Menéndez Maceiras | 295 | 7 | |
| Spain | Roberto Ortega Olmedo | 299 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as special exempts:
The following players received entry from the qualifying draw:
See main article: 2021 Salinas Challenger II – Singles.
Emilio Gómez def. Nicolás Jarry 4–6, 7–6(8–6), 6–4.See main article: 2021 Salinas Challenger II – Doubles.
Nicolás Barrientos / Sergio Galdós def. Antonio Cayetano March / 
Thiago Agustín Tirante Walkover.