See main article: 2021 Salinas Challenger.
Roberto Maytín and Fernando Romboli were the defending champions[1] but only Romboli chose to defend his title, partnering Miguel Ángel Reyes-Varela.
Romboli successfully defended his title, defeating Diego Hidalgo and Skander Mansouri 7–5, 4–6, [10–2] in the final.