| Date: | 19–25 April |
| Edition: | 20th |
| Surface: | Hard |
| Location: | Salinas, Ecuador |
| Champs: | Nicolás Jarry |
| Champd: |  Miguel Ángel Reyes-Varela /  Fernando Romboli |
| Before Year: | 2014 |
| Before Name: | Challenger ATP de Salinas Diario Expreso |
| After Year: | 2021 |
| After Name: | Salinas Challenger II |
The 2021 Salinas Challenger was a professional tennis tournament played on hard courts. It was the 20th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Salinas, Ecuador between 19 and 25 April 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Japan | Yasutaka Uchiyama | 108 | 1 | |
| Alejandro Tabilo | 163 | 2 | ||
 Ecuador | Emilio Gómez | 183 | 3 | |
| Christopher Eubanks | 233 | 4 | ||
| Marcelo Tomás Barrios Vera | 239 | 5 | ||
 Turkey | Altuğ Çelikbilek | 251 | 6 | |
| Japan | Hiroki Moriya | 266 | 7 | |
| Ecuador | Roberto Quiroz | 273 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2021 Salinas Challenger – Singles.
Nicolás Mejía 7–6(9–7), 6–1.See main article: 2021 Salinas Challenger – Doubles.
Miguel Ángel Reyes-Varela / Fernando Romboli def. Diego Hidalgo / 
Skander Mansouri 7–5, 4–6, [10–2].
