| Year: | 2021 |
| Team: | Saint Francis Red Flash |
| Sport: | football |
| Conference: | Northeast Conference |
| Short Conf: | NEC |
| Record: | 5–6 |
| Conf Record: | 4–3 |
| Head Coach: | Chris Villarrial |
| Hc Year: | 11th |
| Off Coach: | Marco Pecora |
| Oc Year: | 2nd season |
| Def Coach: | Scott Lewis |
| Dc Year: | 1st |
| Stadium: | DeGol Field |
| Prev Year: | 2019 |
The 2021 Saint Francis Red Flash football team represented Saint Francis University as a member of the Northeast Conference (NEC) in the 2021 NCAA Division I FCS football season. The Red Flash, led by 11th-year head coach Chris Villarrial, played their home games at DeGol Field.