See main article: 2021 Quito Challenger.
Marcelo Arévalo and Miguel Ángel Reyes-Varela were the defending champions[1] but chose not to defend their title.
Alejandro Gómez and Thiago Agustín Tirante won the title after defeating Adrián Menéndez Maceiras and Mario Vilella Martínez 7–5, 6–7(5–7), [10–8] in the final.