| Date: | 8–14 February |
| Edition: | 2nd |
| Surface: | Hard |
| Location: | Potchefstroom, South Africa |
| Champs: |  Benjamin Bonzi |
| Champd: | Marc-Andrea Hüsler /  Zdeněk Kolář |
| After Name: | Potchefstroom Open II |
| After Year: | 2021 |
The 2021 Potchefstroom Open was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Potchefstroom, South Africa between 8 and 14 February 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 India | Prajnesh Gunneswaran | 130 | 1 | |
| France | Benjamin Bonzi | 134 | 2 | |
| Marc-Andrea Hüsler | 143 | 3 | ||
 United Kingdom | Jay Clarke | 190 | 4 | |
 Canada | Brayden Schnur | 208 | 5 | |
 Turkey | Cem İlkel | 214 | 6 | |
| Canada | Peter Polansky | 220 | 7 | |
 Dominican Republic | Roberto Cid Subervi | 222 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw using protected rankings:
The following players received entry from the qualifying draw:
See main article: 2021 Potchefstroom Open – Singles.
Benjamin Bonzi def. Liam Broady 7–5, 6–4.See main article: 2021 Potchefstroom Open – Doubles.
Zdeněk Kolář def. Peter Polansky / Brayden Schnur 6–4, 2–6, [10–4].
