| Year: | 2021 |
| Team: | Penn Quakers |
| Sport: | football |
| Conference: | Ivy League |
| Short Conf: | Ivy |
| Record: | 3–7 |
| Conf Record: | 1–6 |
| Head Coach: | Ray Priore |
| Hc Year: | 6th |
| Off Coach: | Kevin Morris |
| Oc Year: | 2nd |
| Def Coach: | Bob Benson |
| Dc Year: | 6th |
| Stadium: | Franklin Field |
| Prev Year: | 2019 |
The 2021 Penn Quakers football team represented the University of Pennsylvania in the 2021 NCAA Division I FCS football season as a member of the Ivy League. The team was led by sixth-year head coach Ray Priore and played its home games at Franklin Field. Penn averaged 4,971 fans per game.