See main article: 2021 Open de Tenis Ciudad de Pozoblanco.
Konstantin Kravchuk and Denys Molchanov were the defending champions[1] but chose not to defend their title.
Igor Sijsling and Tim van Rijthoven won the title after defeating Diego Hidalgo and Sergio Martos Gornés 5–7, 7–6(7–4), [10–5] in the final.