| Date: | 27 September – 3 October |
| Edition: | 16th |
| Surface: | Hard (Indoor) |
| Location: | Orléans, France |
| Champs: | Henri Laaksonen |
| Champd: |  Pierre-Hugues Herbert / Albano Olivetti |
| Before Year: | 2019 |
The 2021 Open d'Orléans was a professional tennis tournament played on indoor hard courts. It was the sixteenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Orléans, France between 27 September and 3 October 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| France | Ugo Humbert | 26 | 1 | |
| France | Benjamin Bonzi | 61 | 2 | |
| France | Arthur Rinderknech | 74 | 3 | |
| France | Richard Gasquet | 81 | 4 | |
 Czech Republic | Jiří Veselý | 88 | 5 | |
| France | Corentin Moutet | 91 | 6 | |
| France | Gilles Simon | 99 | 7 | |
| France | Pierre-Hugues Herbert | 100 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 Open d'Orléans – Singles.
Dennis Novak 6–1, 2–6, 6–2.See main article: 2021 Open d'Orléans – Doubles.
Pierre-Hugues Herbert / Albano Olivetti def. Antoine Hoang / Kyrian Jacquet 6–2, 2–6, [11–9].
