| Score: | 6–2, 7–5 |
| Draw: | 16 |
| Seeds: | 4 |
| Type: | singles doubles |
See main article: 2021 Open Sud de France.
Nikola Ćaćić and Mate Pavić were the defending champions,[1] but they chose not to participate this year. Henri Kontinen and Édouard Roger-Vasselin won the title, defeating Jonathan Erlich and Andrei Vasilevski in the final, 6–2, 7–5.