| Date: | 1–7 February |
| Edition: | 12th |
| Surface: | Hard (Indoor) |
| Location: | Quimper, France |
| Champs: |  Brandon Nakashima |
| Champd: |  Ruben Bemelmans / Daniel Masur |
| Main Name: | Open Quimper Bretagne |
| Before Name: | Open Quimper Bretagne |
| Before Year: | 2021 |
| After Name: | Open Quimper Bretagne |
The 2021 Open Quimper Bretagne II was a professional tennis tournament played on hard courts. It was the twelfth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Quimper, France between 1 and 7 February 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Alejandro Davidovich Fokina | 54 | 1 | |
 France | Lucas Pouille | 74 | 2 | |
| France | Grégoire Barrère | 111 | 4 | |
| Denis Kudla | 116 | 5 | ||
| France | Antoine Hoang | 119 | 6 | |
| France | Arthur Rinderknech | 135 | 7 | |
 Italy | Federico Gaio | 136 | 8 |
The following players received wildcards into the singles main draw:
Arthur Cazaux Antoine Cornut Chauvinc Manuel GuinardThe following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 Open Quimper Bretagne II – Singles.
Brandon Nakashima def. Bernabé Zapata Miralles 6–3, 6–4.See main article: 2021 Open Quimper Bretagne II – Doubles.
Ruben Bemelmans / Daniel Masur def. Brandon Nakashima / Hunter Reese 6–2, 6–1.