| Date: | 28 June–4 July 2021 |
| Edition: | 15th |
| Surface: | Clay |
| Location: | Montpellier, France |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Anhelina Kalinina |
| Champd: |  Estelle Cascino /  Camilla Rosatello |
| Before Year: | 2019 |
| After Name: | Open International Féminin de Montpellier |
The 2021 Open Montpellier Méditerranée Métropole Hérault is a professional women's tennis tournament played on outdoor clay courts. It is the fifteenth edition of the tournament which is part of the 2021 ITF Women's World Tennis Tour. It takes place in Montpellier, France between 28 June and 4 July 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| France | Océane Dodin | 114 | 1 | |
 Egypt | Mayar Sherif | 117 | 2 | |
| Ukraine | Anhelina Kalinina | 125 | 3 | |
| France | Harmony Tan | 132 | 4 | |
 Australia | Maddison Inglis | 140 | 5 | |
| Francesca Di Lorenzo | 155 | 6 | ||
 Spain | Cristina Bucșa | 166 | 7 | |
| Grace Min | 179 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry using a protected ranking:
The following player received entry as a junior exempt:
The following player received entry as a special exempt:
The following players received entry from the qualifying draw:
Valentina Ivakhnenko Guiomar Maristany
Yuriko Lily Miyazaki
Sada Nahimana Oksana Selekhmeteva Dalila Spiteri Margot YerolymosSee main article: 2021 Open Montpellier Méditerranée Métropole Hérault – Singles.
Anhelina Kalinina def. Mayar Sherif, 6–2, 6–3See main article: 2021 Open Montpellier Méditerranée Métropole Hérault – Doubles.
Estelle Cascino / Camilla Rosatello def. Liang En-shuo / 
Yuan Yue, 6–3, 6–2