| Date: | 20–26 September 2021 |
| Edition: | 5th |
| Surface: | Clay |
| Location: | Valencia, Spain |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $80,000 |
| Champs: | Arantxa Rus |
| Champd: |  Aliona Bolsova /  Andrea Gámiz |
| Main Name: | Open Ciudad de Valencia |
| Before Year: | 2019 |
| Before Name: | BBVA Open Ciudad de Valencia |
The 2021 Open Ciudad de Valencia was a professional women's tennis tournament played on outdoor clay courts. It was the fifth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Valencia, Spain between 20 and 26 September 2021.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Arantxa Rus | 75 | 1 | ||
 Italy | ||||
| Italy | ||||
 Romania | Irina Bara | 118 | 4 | |
 Slovakia | Kristína Kučová | 119 | 5 | |
 Hungary | Dalma Gálfi | 138 | 6 | |
 Georgia | Ekaterine Gorgodze | 158 | 7 | |
 United Kingdom | Francesca Jones | 160 | 8 | |
| Spain | Aliona Bolsova | 166 | 9 |
The following players received wildcards into the singles main draw:
The following player received entry using a junior exempt:
The following players received entry from the qualifying draw:
Naiktha Bains Marina Bassols Ribera Ilona Georgiana Ghioroaie María Gutiérrez Carrasco
Funa Kozaki Andreea Prisăcariu Leyre Romero Gormaz
Iryna ShymanovichThe following players received entry as lucky losers:
Amanda Carreras Eva Guerrero ÁlvarezSee main article: 2021 Open Ciudad de Valencia – Singles.
Mihaela Buzărnescu, 6–4, 7–6(7–3)See main article: 2021 Open Ciudad de Valencia – Doubles.
Aliona Bolsova / Andrea Gámiz def. Ekaterine Gorgodze / 
Laura Pigossi, 6–3, 6–4