See main article: 2021 Open Bogotá.
Marcelo Arévalo and Miguel Ángel Reyes-Varela were the defending champions[1] but chose not to defend their title.
Nicolás Jarry and Roberto Quiroz won the title after defeating Nicolás Barrientos and Alejandro Gómez 6–7(4–7), 7–5, [10–4] in the final.