| Year: | 2021 |
| Team: | Norfolk State Spartans |
| Sport: | football |
| Conference: | Mid-Eastern Athletic Conference |
| Short Conf: | MEAC |
| Record: | 6–5 |
| Conf Record: | 2–3 |
| Head Coach: | Dawson Odums |
| Hc Year: | 1st |
| Off Coach: | B. T. Sherman |
| Def Coach: | Steve Adams |
| Dc Year: | 1st |
| Stadium: | William "Dick" Price Stadium |
| Prev Year: | 2019 |
The 2021 Norfolk State Spartans football team represented Norfolk State University as a member of the Mid-Eastern Athletic Conference (MEAC) in the 2021 NCAA Division I FCS football season. The Spartans, led by first-year head coach Dawson Odums, played their home games at William "Dick" Price Stadium.