| 2021 NCAA Division I softball season | |
| Duration: | February 2021 – June 2021 |
| Preseason1: | (Unanimous) |
| Defendingchampions: | UCLA |
| Tv: | ESPN |
| Tournament Link: | 2021 NCAA Division I softball tournament |
| Tournament: | NCAA Tournament |
| Tourneyduration: | May 20 – June 10, 2021 |
| Conferencebids: | SEC, 12 teams |
| Wcwsduration: | June 3–10, 2021 |
| Wcws Link: | 2021 Women's College World Series |
| Wcws: | Women's College World Series |
| Wcwschamp: | Oklahoma |
| Wcwstitlecount: | 5th |
| Wcwscount: | 14th |
| Wcwscoach: | Patty Gasso |
| Wcwscoachcount: | 5th |
| Wcwsmop: | Giselle Juarez |
| Mopteam: | Oklahoma |
| Prevseason Year: | 2020 |
| Nextseason Year: | 2022 |
The following human polls made up the 2021 NCAA Division I women's softball rankings. The NFCA/USA Today Poll was voted on by a panel of 32 Division I softball coaches. The NFCA/USA Today poll, the Softball America poll, the ESPN.com/USA Softball Collegiate rankings, and D1Softball ranked the top 25 teams nationally.
| Increase in ranking | |||
| Decrease in ranking | |||
| Not ranked previous week | |||
| Italics | Number of first place votes | ||
| (#-#) | Win–loss record | ||
| т | Tied with team above or below also with this symbol |
Source:[1]